The PIVOTAL trial is the world’s first PIC specific Platform trial. It comes hot on the heels of some brilliant UK PIC research, like OxyPICU (PicPod77), and GASTRIC (not published yet, but will definitely have a PicPod soon!).
It’s a platform which aims to reduce the life cycle of PIC research from about 10 years from idea to publication, down towards one half, or one third. All UK PICUs have signed up to this.
We discuss the ethics, methodology, and statistics (spoiler alert: PicPod65 will help). We go through the aims, and hoped for end points. We discuss each of the three starting arms, (restrictive vs standard fluids, midazolam vs dexmedetomidine or clonidine, and various transfusion thresholds).
It’s a study of ambition and huge scope, with an aim of recruiting as many PIC admissions as possible.
For UK listeners it’s a must: for those in other countries it’s an example of how PICUs can work together to build a platform like this.
Enjoy!
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